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CURRENT VACANCIES

 

R&D Laboratory Technician – Reagent Characterisation

We are looking for a laboratory technician to carry out experiments, as directed by the Lead Scientist, to aid research into new analytical methods for the characterisation of RPA reagents and components. We are looking for someone with a strong knowledge of analytical chemistry and techniques for biomolecule characterisation, ideally with good molecular biology laboratory skills, to work within a small team in our R&D department.

Duties include the characterisation of RPA reagents and components using a variety of analytical techniques e.g. (U)HPLC, gel electrophoresis, NMR, UV-Vis spectroscopy, ICP-OES. They will develop (U)HPLC and LCMS methods for biomolecule characterisation and will run RPA reactions using company devices.

The successful candidate will be able to record, analyse and report data effectively; they will be able to work as part of a small collaborative team. Duties will also include routine equipment maintenance and calibration and general laboratory management duties such as ordering consumables. 

This role is based at our R&D department on Babraham Research Campus, Cambridge, UK.

To apply please send your CV and a letter of application to janet@twistdx.co.uk. Please quote TWRDLT07112016.


Senior Process Development Scientist

We are looking for a scientist to join our Protein Development team. This position will play a lead role in the development of protein manufacturing processes to allow scale-up and consequent transfer into large-scale manufacturing.

The successful candidate will:

• develop and optimise protein production processes using E.coli cultures and transfer them from a development environment into manufacturing. This will include devising new processes and refining existing ones; developing scale-up procedures for fermentation; optimising fermentation processes (feed strategy, pH, temperature, stirring)
• plan and implement feasibility studies, process trials and validation exercises
• source materials and equipment as well as  write and implement new procedures
• translate company objectives into deliverables.

You will have strong experience within fermentation process development.  Experience in the development of protein production processes from E.coli and strong experience in bioreactors are critical for this role. 

Candidates will ideally hold a PhD in Biochemistry, Microbiology or a related area although candidates with a clear research mind-set with strong experience will also be considered. If you are familiar with the development of IVD products, GMP and quality management systems this will also be an advantage though not essential.

Should you wish to apply, please send your CV with a covering letter to Janet@twistdx.co.uk. Please quote reference TWSS02112016. This role is based at our Cambridge Science Park site on Milton road.


R&D Laboratory Technician – Transfer to Manufacturing

We are looking for a laboratory technician to carry out routine laboratory work to support the development of in vitro diagnostic assays using the company’s revolutionary RPA technology. Moreover, this role is part of the team whose function is to successfully transfer the technology into manufacturing settings. We are looking for someone with strong molecular biology laboratory skills to work within a small team in our R&D department on specific projects.

The main responsibility of this role is to perform RPA assays, troubleshoot, generate and analyse data. The successful candidate will be able to work with some autonomy, report effectively on their work, analyse data and gain enough knowledge about the technology to be able to troubleshoot where necessary. They will also be part of the team who are responsible for general laboratory housekeeping duties within the R&D department and will also perform routine equipment maintenance and calibration. 

This role is based at our R&D department at Babraham Research Campus, Cambridge.

To apply please send your CV and a letter of application to janet@twistdx.co.uk. Please quote TWRDLT01112016.


 

Process Development Specialist

We are looking for someone with proven hands-on laboratory-based experience performing protein purification using the AKTA systems and associated software packages.  Practical experience in buffer preparation, buffer exchange, protein gel electrophoresis is essential. This role is vital to the ongoing development of the protein purification process at TwistDx. The successful candidate will be responsible for conducting experiments in protein purification as directed by the scientist leading the work in this area. He/she will perform the associated analysis and presentation and also have the opportunity to participate in discussions about the direction of the work. An ability to troubleshoot where necessary will be expected.

General laboratory duties including equipment maintenance and calibration, preparing of procedural documents, and conduction of work in accordance with the company quality management system, are also part of this role. If you have a background in protein purification and wish to apply please send your CV with a covering letter to Janet@twistdx.co.uk. Please quote reference TWPDS25102016 in your application. This role is based at the company’s production site on the Cambridge Science Park.


Production Laboratory Technician (Fermentation)

TwistDx Ltd is looking for a Production Laboratory Technician to manufacture proteins and reagents for its production facility at the Cambridge Science Park, Milton Road.

The successful candidate will take responsibility for large-scale protein production using large scale (100L) fermentation processes and associated laboratory tasks.

Specific responsibilities include:

• manufacturing of bulk proteins (via microbial fermentation) and reagents in accordance with approved protocols within the protein team as required
• completion of all documentation in accordance with the quality management system
• completion of in-process QC testing
• general housekeeping duties associated with all areas of the facility
• performance of routine equipment maintenance and calibration
• assisting in equipment and process validation work
• scheduling weekly work within a small team in order to successfully achieve work plans set in advance by management
• making suggestions and participating in our process improvement programme to ensure continuous improvement in quality and efficiency within the production department.

We are looking for someone with relevant laboratory experience preferably in a production environment and/or a science graduate looking to start their career in production science.

Experience working within an ISO accredited environment is advantageous but not essential.

Should you wish to apply please send your CV with a covering letter to Janet@twistdx.co.uk. No agencies please. Please quote reference TWPLTFER 26092016 in your application.