Publications

Publications

Every year more and more scientists are finding out that RPA really works. Over 350 peer-reviewed publications* have been written as people discover the benefits of RPA. See the publications on this page to give you inspirational ideas of how you could use RPA for experiments that just aren't possible with PCR.

*TwistDx takes no responsibility for the content of the publications or their author/s.

  • RPA combined with a lateral flow dipstick for discriminating between infectious Penaeus stylirostris

    Author: Jaroenram W, Owens L

    Recombinase Polymerase Amplification combined with a lateral flow dipstick for discriminating between infectious Penaeus stylirostris densovirus and virus-related sequences in shrimp genome.

  • Quantification of HIV-1 DNA using Real-Time Recombinase Polymerase Amplification

    Author: Zachary Austin Crannell, Brittany Rohrman, and Rebecca Richards-Kortum

    This paper describes the use of an internal control and an algorithm to quantify HIV-1 DNA using TwistAmp exo reactions.

  • Development of a RPA Assay for the Detection of Pathogenic Leptospira

    Author: Ahmed Ahmed, Hans van der Linden and Rudy A. Hartskeerl

    Leptospirosis is a difficult to disease to diagnose. Researchers from KIT Biomedical Research have developed an RPA test that can detect

  • Rapid and sensitive detection of Little cherry virus 2 using isothermal reverse transcription- RPA

    Author: Tefera A. Mekuriaa, Shulu Zhangb, Kenneth C. Eastwella

    RT-RPA and lateral flow used to detect the Little cherry virus 2 coat protein gene. RT-RPA was simple, fast, and specific. The test has the sensitivity of RT-PCR and is more cost effective, being capable of detecting the virus from […]

  • Real-Time Isothermal Detection of Shiga Toxin-Producing Escherichia coli Using RPA

    Author: Murinda SE, Ibekwe AM, Zulkaffly S, Cruz A, Park S, Razak N, Paudzai FM, Ab Samad L, Baquir K,Muthaiyah K, Santiago B, Rusli A, Balkcom S

    RPA assays developed to detect Shiga toxin-producing Escherichia coli (STEC), a major family of foodborne pathogens of public health, zoonotic, and economic significance in the United States and worldwide.

  • One-step digital plasma separation for molecular diagnostics

    Author: Erh-Chia Yeh and Luke P. Lee

    First demonstration of the coupling of digital plasma separation with RPA nucleic acid detection directly from blood samples.

  • Rapid detection of Schmallenberg Virus & Bovine Viral Diarrhoea Virus using isothermal amplification

    Author: Aebischer A, Wernike K, Hoffmann B, Beer M

    Among a wide range of available technologies, high-speed real-time reverse transcriptase quantitative PCR (RT-qPCR) and the two isothermal amplification techniques loop-mediated isothermal amplification (LAMP) and recombinase polymerase amplification (RPA) represent three promising candidates for integration into mobile pen-side tests.

  • A Fully Integrated Lab-on-a-Disc for Nucleic Acid Analysis of Food-borne Pathogens

    Author: Tae-Hyeong Kim, Juhee Park, Chi-Ju Kim, and Yoon-Kyoung Cho

    TwistFlow® Salmonella tests integrated into a centrifugal microfluidic device that performs DNA extraction, amplification and detection onto a single disc. DNA extraction to readout took 30 minutes with sensitivities of 10 CFU/ml of PBS and 100 CFU/ml of milk.

  • Rapid detection of Plasmodium falciparum with isothermal recombinase polymerase amplification

    Author: Sebastian Kersting, Valentina Rausch, Frank Fabian Bier, and Markus von Nickisch-Rosenegk

    A TwistAmp nfo-based test for the 18S rRNA gene of P. falciparum detected as few as four parasites after

  • Rapid Molecular Assays for the Detection of Yellow Fever Virus in Low-Resource Settings

    Author: Escadafal C, Faye O, Sall AA, Faye O, Weidmann M, Strohmeier O, von Stetten F, Drexler J, Eberhard M, Niedrig M, Patel P

    RPA assays were developed to detect Yellow Fever Virus on three different platforms (real-time with or without microfluidic semi-automated system and lateral-flow assay). The assay was able to detect 20 different YFV strains with no cross-reactions with closely related viruses. […]

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